Ten tec triton iv resonate
Injury to the neurotrophin secreting cells in the inner ear is followed by irreversible degeneration of spiral ganglion neurons with consequences such as impaired hearing or deafness. The neurotrophins BDNF and NT3 provide essential trophic support to auditory neurons.
![ten tec triton iv resonate ten tec triton iv resonate](https://i.ytimg.com/vi/ocOmfmoyk8o/sddefault.jpg)
The precursor of the neurotrophin NGF (proNGF) serves physiological functions distinct from its mature counterpart as it induces neuronal apoptosis through activation of a p75 neurotrophin receptor (p75 NTR) and Sortilin death-signalling complex. OHC outer hair cells, IHC inner hair cells, SGNT spiral ganglion nerve terminals, VGNT vestibular ganglion nerve terminals, HC-I type-1 hair cells, SGN spiral ganglion neurons, MC strial marginal cells. Note the lack of immunolabelling in pre-incubated tissue samples (G+H) compared to the positive control (E+F), where labelling was not preceded by pre-incubation with soluble Sortilin. Sortilin antibody specificity was demonstrated by pre-incubation with soluble Sortilin (130 μg/ml) prior to incubation with the primary Sortilin antibody (5.6 μg/ml).
![ten tec triton iv resonate ten tec triton iv resonate](https://cdn-bio.qrz.com/m/w6jim/triton_iv.jpg)
(E–H) Anti-Sortilin labelling of spiral ganglion neurons and strial marginal cells in the cochlea. Note the identical staining of anti-p75 NTR labelled and nerve specific anti-Tuj1 labelled presynaptic nerve terminals in the organ of Corti as well as the organization of hair cells and their innervating afferent neurons in the saccular macula. Anti-p75 NTR labelling of nerve terminals and Sortilin antibody specificity (A–D) Double immunolabelling of hair cells and nerve terminals in the organ of Corti (A+C) and in the saccular macula (B+D) using a specific hair cell marker (anti-myosin VIIa), a nerve specific marker (anti-Tuj1 class III β-tubulin) and anti-p75 NTR.